Antineoplastic Medications

Antineoplastic medications such as mitotane (Lysodren), chlorambucil (Leukeran), and azathioprine (Imuran) are usually teratogenic but can also be mutagenic, carcinogenic, and abortigenic. The principle governing working with cytotoxics is to keep exposure as low as possible. This may necessitate premix syringes and bottles prepared at a pharmacy under special mixing hoods, personal protective equipment, and isolation procedures. The clients and other people close to the patient are also potentially at risk and should be told of this and informed about drug administration and the disposal of feces, vomit, urine, saliva, and blood that may contain the active pharmaceutical. The prescription and/or administration of cytotoxic drugs, including those that are used as immunosuppressive agents in veterinary medicine, should be restricted to specialist veterinarians who have adequate knowledge and appropriate facilities to work with these agents (33,34).

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