Clinical Signs and Symptoms

Signs and symptoms resemble other types of viral hepatitis. Abdominal pain, anorexia, dark urine, fever, hepatomegaly, jaundice, malaise, nausea, and vomiting are seen. Less common manifestations include arthralgias, diar rhea, pruritis, and urticaria. Fulminant hepatitis may develop, especially in pregnant women. The overall mortality ranges from 1% to 3% but may be as high as 25% (higher in some studies) during pregnancy. Death of the fetus, abortion, premature delivery, or death of a live-born soon after birth are common complications of hepatitis E infection during pregnancy. Vertical transmission has been reported to occur in 33% to 100% of cases (5-9).

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