Acquired, noninfectious granulomas of the skin can have animate or inanimate causes. The most common animate granuloma is pyogenic granuloma, a polymorphous, irregular tumor that arises out of burned, abraded, or otherwise damaged skin. Pyogenic granulomas can be mistaken for BCC. Treatment is excision followed by electrodesiccation (49).

The most common inanimate cause of granuloma is foreign bodies. Foreign-body granulomas can be caused by almost any foreign body that gets lodged in the dermis and causes a foreign-body inflammatory reaction. Examples in agriculture are thorns from citrus trees and splinters from lumber. Treatment is excision, and antibiotics may be necessary for secondary infections (49).

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