References

Adye J and Mateles RI (1964). Incorporation of labeled compounds into aflatoxins. Biochim Biophys Acta 86:418-420.

Alexander NJ, Hohn TM, and McCormick SP (1998). The TRI11 gene of Fusarium sporotrichioides encodes a cytochrome P-450 monooxygenase required for C-15 hydroxylation in trichothecene biosynthesis. Appl Environ Microbiol 64(1):221-225.

Alexander NJ, McCormick SP, and Hohn TM (1999). TRI12, a trichothecene efflux pump from Fusarium sporotrichioides:

gene isolation and expression in yeast. Mol Gen Genet 261(6):977-984.

Bennett JW (1981). Loss of norsolorinic acid and aflatoxin production by a mutant of Aspergillus parasiticus. J Gen Microbiol 124:429-432.

Bennett JW (1987). Mycotoxigenic fungi in southern crops: interaction of fungal genetics and environmental factors that influence selection of toxin-producing populations. Final Report Cooperative Agreement. 58-7B30-3-556.

Bennett JW and Papa KE (1988). The aflatoxigenic Aspergillus. In: Genetics of Plant Pathogenic Fungi. London: Academic. pp 264-280.

Bennett JW, Lee LS, and Cucullu AF (1976). Effect of dichlorvos on aflatoxin and versicolorin A production in Aspergillus parasiticus. Bot Gaz 137(4):318-324.

Bennett JW, Rubin PL, Lee LS, and Chen PN (1979). Influence of trace elements and nitrogen sources on versicolorin production by a mutant strain of Aspergillus parasiticus. Mycopathologia 69(3):161-166.

Bennett JW, Lee LS, Shoss SM, and Boudreaux GH (1980). Identification of averantin as an aflatoxin Bj precursor: placement in the biosynthetic pathway. Appl Environ Microbiol 39(4):835-839.

Bennett JW, Leong PM, Kruger S, and Keyes D (1986). Sclerotial and low aflatoxigenic morphological variants from haploid and diploid Aspergillus parasiticus. Experientia 42:841-851.

Bennett JW, Bhatnagar D, and Chang PK (1994). The molecular genetics of aflatoxin biosynthesis. FEMS-Symp Madison, Wisconsin, 69. Science Tech. Publishers. pp 51 -58.

Bennett JW, Chang PK, and Bhatnagar D (1997). One gene to whole pathway: the role of norsolorinic acid in aflatoxin research. Adv Appl Microbiol 45:1-15.

Betina V (1989). Mycotoxins: Chemical, Biological and Environmental Aspects. Amsterdam: Elsevier Publisher.

Bezuidenhout CS, Gelderblom WCA, Gorst-Allman CP, Horak RM, Marasas WFO, Spiteller G, and Bleggaar R (1988). Structure education of fumonisins, mycotoxins from Fusarium moniliforme. J Chem Soc Chem Commun:743-745.

Bhatnagar D, Ullah AHJ, and Cleveland TE (1988). Purification and characterization of a methyltransferase from Aspergillus parasiticus SRRC 163 involved in aflatoxin biosynthetic pathway. Prep Biochem 18(3):321-349.

Bhatnagar D and Cleveland TE (1990). Purification and characterization of a reductase from Aspergillus parasiticus SRRC 2043 involved in aflatoxin biosynthesis. FASEB J 4:A2164.

Bhatnagar D, Cleveland TE, and Kingston DGI (1991). Enzymolo-gical evidence for separate pathways for aflatoxin B1 and B2 biosynthesis. Biochem 30:4343-4350.

Bhatnagar D, Ehrlich KC, and Cleveland TE (1992). Oxidation-reduction reactions in biosynthesis of secondary metabolites. In: Bhatnagar D, Lillehoj EB, Arora DK eds. Handbook of Applied Mycology: Mycotoxins in Ecological Systems. New York: Marcel Dekker. pp 255-286.

Bhatnagar D, Ehrlich KC, and Cleveland TE (1993). Biochemical characterization of an aflatoxin B2 producing mutant of Aspergillus flavus. FASEB J 7:1234.

Bhatnagar D, Cleveland TE, Brown RL, Cary JW, Yu J, and Chang P-K (1998). Dhaliwal GS, Arora R, Randhawa NS eds. Preharvest aflatoxin contamination: elimination through biotechnology. Ecological Agriculture and Sustainable

Development. Luhiana, India: Indian Ecological Society. pp 100-129.

Bhatnagar D, Yu J, and Ehrlich KC (2002). Toxins of filamentous fungi. In: Breitenbach M, Crameri R, Lehrer SB eds. Fungal Allergy and Pathogenicity. Vol. 81. Chem. Immunol. Basel, Karger. pp 167 -206.

Brown RL, Bhatnagar D, Cleveland TE, and Cary JW (1998). Recent advances in preharvest prevention of mycotoxin contamination. In: Sinha KK, Bhatnagar D eds. Mycotoxins in Agriculture and Food Safety. New York: Marcel Dekker. pp 351-379.

Brown DW, Adams TH, and Keller NP (1996a). Aspergillus has distinct fatty acid synthases for primary and secondary metabolism. Proc Natl Acad Sci USA:14873-14877.

Brown DW, Yu J-H, Kelkar HS, Fernandes M, Nesbitt TC, Keller NP, Adams TH, and Leonard TJ (1996b). Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proc Natl Acad Sci USA 93:1418-1422.

Brown DW, McCormick SP, Alexander NJ, Proctor RH, and Desjardins AE (2001). A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum. Fungal Genet Biol 32:121-133.

Buchanan RL and Stahl HG (1984). Ability of various carbon sources to induce and support aflatoxin biosynthesis by Aspergillus parasiticus. J Food Saf 6:271-279.

Busby WF, Jr and Wogan GN (1981). Aflatoxins. In: Mycotoxins and N-nitrosocompounds: Environmental Risks. Vol. 2. Boca Raton, FL: CRC Press. pp 3-45.

Cane DE, Shim JH, Xue Q, Fitzsimons BC, and Hohn TM (1995). Trichodiene synthase. Identification of active site residues by site-directed mutagenesis. Biochem 34(8):2480-2488.

Cary JW, Wright M, Bhatnagar D, Lee R, and Chu FS (1996). Molecular characterization of an Aspergillus parasiticus dehydrogenase gene, norA, located on the aflatoxin biosynthesis gene cluster. Appl Environ Microbiol 62(2):360-366.

Cary JW, Ehrlich KC, Wright M, Chang PK, and Bhatnagar D (2000a). Generation of aflR disruption mutants of Aspergillus parasiticus. Appl Microbiol Biotechnol 53(6):680-684.

Cary JW, Montalbano BG, and Ehrlich KC (2000b). Promoter elements involved in the expression of the Aspergillus parasiticus aflatoxin biosynthesis pathway gene avnA. Biochim Biophys Acta 1491(1-3):7-12.

CAST (1989). Mycotoxins, Economics and Health Risks. Council of Agricultural Science and Technology (CAST), Task force report No. 116. CAST, AMES, IA, p 92.

Chang P-K and Yu J (2002). Characterization of a partial duplication of the aflatoxin gene cluster in Aspergillus parasiticus ATCC 56775. Appl. Microbiol Biotechnol 58:632-636.

Chang P-K, Skory CD, and Linz JE (1992). Cloning of a gene associated with aflatoxin biosynthesis in Aspergillus parasiticus. Curr Genet 21:231-233.

Chang P-K, Cary JW, Bhatnagar D, Cleveland TE, Bennett JW, Linz JE, Woloshuk CP, and Payne GA (1993). Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis. Appl Environ Microbiol 59(10):3273-3279.

Chang P-K, Cary JW, Yu J, Bhatnagar D, and Cleveland TE (1995a). Aspergillus parasiticus polyketide synthase gene, pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1. Mol Gen Genet 248:270-277.

Chang P-K, Ehrlich KC, Yu J, Bhatnagar D, and Cleveland TE (1995b). Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA binding protein, relieves nitrate inhibition of aflatoxin biosynthesis. Appl Environ Microbiol 61(6):2372-2377.

Chang P-K, Ehrlich KC, Linz JE, Bhatnagar D, Cleveland TE, and Bennett JW (1996). Characterization of the Aspergillus niaD and niiA gene cluster. Curr Genet 30:68-75.

Chang P-K, Yu J, Bhatnagar D, and Cleveland TE (1999a). Repressor-AFLR interaction modulates aflatoxin biosynthesis in Aspergillus parasiticus. Mycopathologia 147:105-112.

Chang P-K, Yu J, Bhatnagar D, and Cleveland TE (1999b). The carboxy-terminal portion of the aflatoxin pathway regulatory protein AFLR of Aspergillus parasiticus activates GAL1:lacZ gene expression in Saccharomyces cerevisiae. Appl Environ Microbiol 65:2058-2512.

Chang P-K, Yu J, Bhatnagar D, and Cleveland TE (2000a). Characterization of the Aspergillus parasiticus major nitrogen regulatory gene, areA. Biochim Biophys Acta 1491:263 -266.

Chang P-K, Yu J, Ehrlich KC, Boue SM, Montalbano BG, Bhatnagar D, and Cleveland TE (2000b). The aflatoxin biosynthesis gene adhA in Aspergillus parasiticus is involved in conversion of 50-hydroxyaverantin to averufin. Appl Environ Microbiol 66:4715-4719.

Chiou CH, Miller M, Wilson DL, Trail F, and Linz JE (2002). Chromosomal location plays a role in regulation of aflatoxin gene expression in Aspergillus parasiticus. Appl Environ Microbiol 68(1):306-315.

Chu FS (1991). Mycotoxins: food contamination, mechanism, carcinogenic potential and preventive measures. Mutat Res 259:291-306.

Chu FS (1997). Trichothecene mycotoxicosis. In: Dulbecco R ed. Encyclopedia of Human Biology. Vol. 8, 2nd Ed. pp 511-522.

Cleveland TE and Bhatnagar D (1991). Molecular regulation of aflatoxin biosynthesis. In: Pennington Center Nutrition Series, Vol. 1, Mycotoxins, Cancer and Health. pp 270-287.

Cleveland TE and Bhatnagar D (1992). Molecular strategies for reducing aflatoxin levels in crops before harvest. In: Bhatnagar D, Cleveland TE eds. Molecular Approaches to Improving Food Quality and Safety. New York: Van Nostrand Reinhold. pp 205 -228.

Cleveland TE, Cary JW, Brown RL, Bhatnagar D, Yu J, Chang PK, Chlan CA, and Rajasekaran K (1997). Use of biotechnology to eliminate aflatoxin in preharvest crops. Bull Inst Compr Agr Sci Kinki Univ 5:75-90.

Cole RJ and Cox EH (1987). Handbook of Toxic Fungal Metabolites. New York: Academic Press.

Cotty PJ (1988). Aflatoxin and sclerotial production by Aspergillus flavus: influence of pH. Phytopath 78:1250-1253.

Cullen JM, Ruebrier BH, Hsieh LS, Hyde DM, and Hsieh DP (1987). Carcinogenicity of dietary aflatoxin M I in male Fischer rats compared to aflatoxin Bj. Cancer Res 47:1913-1917.

Davis ND, Diener UL, and Agnihotri VP (1967). Production of aflatoxins B1 and G1 in chemically defined medium. Mycopathol Mycol Appl 31:251-256.

Demain AL (1972). Cellular and environmental factors affecting the synthesis and excretion of metabolites. J Appl Chem Biotechnol 22:345-372.

Desjardins AE and Proctor RH (1999). Biochemistry and genetics of Fusarium toxins. In: Summerell B, Leslie JF, Backhouse D, Bryden WL, Burgess LW eds. Fusarium: Paul E. Nelson Symposium. St. Paul: APS Press. pp 51-70.

Desjardins AE, Plattner RD, and Beremand MN (1987). Ancymidol blocks trichothecene biosynthesis and leads to accumulation of trichodiene in Fusarium sporotrichioides and Gibberella pulicaris. Appl Environ Microbiol 53(8):1860-1865.

Desjardins AE, Hohn TM, and McCormick SP (1993). Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol Rev 57(3):595-604.

Desjardins AE, Plattner RD, Nelsen TC, and Leslie JF (1995). Genetic analysis of fumonisin production and virulence of Gibberella fujikuroi mating population A (Fusarium monili-forme) on maize (Zea mays) seedlings. Appl Environ Microbiol 61(1):79-86.

Desjardins AE, Plattner RD, and Proctor RH (1996a). Genetic and biochemical aspects of fumonisin production. In: Jackson LS, DeVries JW, Bullerman LB eds. Fumonisins in Food. New York: Plenum Press. pp 165-173.

Desjardins AE, Plattner RD, and Proctor RH (1996b). Linkage among genes responsible for fumonisin biosynthesis in Gibberella fujikuroi mating population A. Appl Environ Microbiol 62(7):2571-2576.

Desjardins AE, Manandhar G, Plattner RD, Maragos CM, Shrestha K, and McCormick SP (2000). Occurrence of Fusarium species and mycotoxins in nepalese maize and wheat and the effect of traditional processing methods on mycotoxin levels. J Agric Food Chem 48(4):1377-1383.

Detroy RW, Freer S, and Ciegler A (1973). Aflatoxin and anthraquinone biosynthesis by nitrosoquanidine-derived mutants of Aspergillus parasiticus. Can J Microbiol 19:1373-1378.

Dutton MF (1988). Enzymes and aflatoxin biosynthesis. Microbiol Rev 52:274-295.

Dutton MF (1996). Fumonisins, mycotoxins of increasing importance: Their nature and their effects. Pharmacol Therap 70:137-161.

Eaton DL and Groopman JD (1994). The Toxicology of Aflatoxins-Human Health. Veterinary and Agricultural Significance. New York: Academic Press.

Ehrlich KC, Montalbano BG, Bhatnagar D, and Cleveland TE (1998). Alteration of different domains in AFLR affects aflatoxin pathway metabolism in Aspergillus parasiticus transformants. Fungal Genet Biol 23(3):279-287.

Ehrlich KC, Cary JW, and Montalbano BG (1999a). Characterization of the promoter for the gene encoding the aflatoxin biosynthetic pathway regulatory protein AFLR. Biochim Biophys Acta 1444(3):412-417.

Ehrlich KC, Montalbano BG, and Cary JW (1999b). Binding of the C6-zinc cluster protein, AFLR, to the promoters of aflatoxin pathway biosynthesis genes in Aspergillus parasiticus. Gene 230(2):249-257.

Eldridge DW (1964). Nutritional factory influencing the synthesis of aflatoxin B1 by Aspergillus flavus. In: MSc thesis Auburn, AL: Auburn. Univ.

Espeso EA, Tilburn J, Arst HN, Jr, and Penalva MA (1993). pH regulation is a major determinant in expression of a fungal biosynthetic gene. EMBO J 12:3947-3956.

Fanelli C and Fabbri AA (1989). Relationship between lipids and aflatoxin biosynthesis. Mycopathologia 107:115-120.

Fanelli C, Fabbri AA, Finotti E, and Passi S (1983). Stimulation of aflatoxin biosynthesis by lipophilic epoxides. J Gen Microbiol 129:1721-1723.

Fanelli C, Fabbri AA, Brasini S, De Luca C, and Passi S (1995). Effect of different inhibitors of sterol biosynthesis on both fungal growth and aflatoxin production. Nat Toxins 3:109-113.

Feng GH and Leonard TJ (1995). Characterization of the polektide synthase gene (pksLl) required for aflatoxin biosynthesis in Aspergillus parasiticus. J Bact 177(21):6246 -6254.

Feng GH and Leonard TJ (1998). Culture conditions control expression of the genes for aflatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and A. nidulans. Appl Environ Microbiol 64(6):2275 - 2277.

Fernandes M, Keller NP, and Adams TH (1998). Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis. Mol Microbiol 28(6):1355-1365.

Fitzell DL, Singh R, Hsieh DPH, and Motell EL (1977). Nuclear magnetic resonance identification of versicolor hemiacetal acetate as an intermediate in aflatoxin biosynthesis. Agric Food Chem 25:1193-1197.

Flaherty JE and Payne GA (1997). Overexpression of afIR leads to upregulation of pathway gene expression and increased aflatoxin production in Aspergillus flavus. Appl Environ Microbiol 63(10):3995-4000.

Frisvad JC and Samson RA (1999). New producers of aflatoxin. In: Samson RA, Pitt JI eds. Interaction of molecular and morphological approaches to Aspergillus and Penicillium taxonomy. Reading: Harwood.

Galvano F, Galofaro V, and Galvano G (1996). Occurrence and stability of aflatoxin MI in milk and milk products: A worldwide review. J Food Protect 59:1079-1090.

Garber RK and Cotty PJ (1997). Formation of sclerotia and aflatoxins in developing cotton bolls infected by the s strain of Aspergillus flavus and potential for biocontrol with an atoxigenic strain. Phytopathol 87(9):940-945.

Gelderblom WCA, Jaskiewiccz K, Marasas WFO, Thiel PG, Horak RM, Vleggaar R, and Kriek NPJ (1988). Fumonisins-Novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl Environ Microbiol 54:1806-1811.

Gelderblom WCA, Krick NPJ, Marasas WFO, and Thiel PG (1991). Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1 in rats. Carcinogenesis 12:1247-1251.

Gelderblom WC, Marasas WFO, Vleggaar R, Thiel PG, and Cawood ME (1992a). Fumonisins: isolation, chemical characterization and biological effects. Mycopathologia 117:11-16.

Gelderblom WC, Semple AE, Marasas WFO, and Farber E (1992b). The cancer-initiating potential of the fumonisin B mycotoxins. Carcinogenesis 13:433-437.

Gelderblom WCA, Cawood ME, Snyman SD, and Marasas WFO

(1993). Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assays. Food Chem. Toxicol 31:407-414.

Gelderblom WCA, Cawood ME, Snyman SD, and Marasas WFO

(1994). Fumonisin Bj dosimetry in relation to cancer initiation in rat liver. Carcinogenesis 15:209-214.

Goldblatt LA (1969). Aflatoxin-Scientific Background, Control and Implications. New York: Acaderitic Press.

Goto T, Wicklow DT, and Ito Y (1996). Aflatoxin and cyclopiazonic acid production by sclerotium-producing Aspergillus tamarii strain. Appl Environ Microbiol 62(11):4036-4038.

Hall AJ and Wild CP (1994). Epidemiology of aflatoxin-related disease. In: Eaton DL, Groopman JD eds. The Toxicology of Aflatoxins: Human Health, Veterinary, and Agricultural Significance. San Diego, C.A. Academic Press. pp 233-258.

Hohn TM and Beremand PD (1989). Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. Gene 79:131-138.

Hohn TM and Desjardins AE (1992). Isolation and gene disruption of the Tox5 gene encoding trichodiene synthase in Gibberella pulicaris. Mol Plant Microbe Interact 5(3):249-256.

Hohn TM, McCormick SP, and Desjardins AE (1993a). Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichioides. Curr Genet 24(4):291-295.

Hohn TM, Desjardins AE, and McCormick SP (1993b). Analysis of Tox5 gene expression in Gibberella pulicaris strains with different trichothecene production phenotypes. Appl Environ Microbiol 59(8):2359-2363.

Hohn TM, Desjardins AE, and McCormick SP (1995). The Tri4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis. Mol Gen Genet 248(1):95-102.

Hohn TM, Krishna R, and Proctor RH (1999). Characterization of a transcriptional activator controlling trichothecene toxin biosynthesis. Fungal Genet Biol 26(3):224-235.

Hsieh DP, Wan CC, and Billington JA (1989). A versiconal hemiacetal acetate converting enzyme in aflatoxin biosynthesis. Mycopathologia 107:121-126.

Huang C, Dickman M, Henderson G, and Jones C (1995). Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungal encoded toxin which is a carcinogen 55:1655-1659.

Jelinek CF, Pohland AE, and Wood GE (1989). Worldwide occurrence of mycotoxins in foods and feeds—an update. J Assoc Off Anal Chem 72:223-230.

Kachholz T and Demain AL (1983). Nitrate repression of averufin and aflatoxin biosynthesis. J Nat Prod 46:499-506.

Kale SP, Bhatnagar D, and Benett JW (1994). Isolation and characterization of morphological variants of Aspergillus parasiticus deficient in secondary metabolite production. Mycol Res 98:645-652.

Kale SP, Cary JW, Bhatnagar D, and Bennett JW (1996). Characterization of experimentally induced, nonaflatoxingenic variant strains of Aspergillus parasiticus. Appl Environ Microbiol 62(9):3399-3404.

Kelkar HS, Keller NP, and Adams TH (1996). Aspergillus nidulans stcP encodes an O-methyltransferase that is required for sterigmatocystin biosynthesis. Appl Environ Microbiol 62(11):4296-4298.

Kelkar HS, Hernant S, Skloss TW, Haw JF, Keller NP, and Adams TH (1997). Aspergillus nidulans stcL encodes a putative cytochrome P-450 monooxygenase required for bisfuran desaturation during aflatoxin/sterigmatocystin biosynthesis. J Biol Chem 272(3):1589-1594.

Keller NP and Hohn TM (1997). Metabolic pathway gene clusters in filamentous fungi. Fungal Genet Biol 21(1):17-29.

Keller NP, Dischinger JHC, Bhatnagar D, Cleveland TE, and Ullah AHJ (1993). Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway. Appl Environ Microbiol 59(2):479-484.

Keller NP, Kantz NJ, and Adams TH (1994). Aspergillus nidulans verA is required for production of the mycotoxin sterigmato-cystin. Appl Environ Microbiol 60(5):1444-1450.

Keller NP, Segner S, Bhatnagar D, and Adams TH (1995a). stcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans. Appl Environ Microbiol 61(10):3628-3632.

Keller NP, Brown D, Butchko RAE, Fernandes M, Kelkar H, Nesbitt C, Segner S, Bhatnagar D, and Adams TE (1995b). A conserved polyketide mycotoxin gene cluster in Aspergillus nidulans. In: Richard JL ed. Molecular Approaches to Food Safety Issues Involving Toxic Microorganisms. Fort Collins, Colorado: Alaken. pp 263-277.

Keller NP, Nesbitt C, Sarr B, Phillips TD, and Burow GB (1997). pH regulation of sterigmatocystin and aflatoxin biosynthesis in Aspergillus spp. Phytopathol 87:643 -648.

Keller NP, Watanabe CMH, Kelkar HS, Adams TH, and Townsend CA (2000). Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans. Appl Environ Microbiol 66:359-362.

Kimura M, Matsumoto G, Shingu Y, Yoneyama K, and Yamaguchi I (1998a). The mystery of the trichothecene 3-O-acetyltrans-ferase gene: analysis of the region around TRI101 and characterization of its homologue from Fusarium sporotrioides. FEBS Lett 435:163-168.

Kimura M, Shingu Y, Yoneyama K, and Yamaguchi I (1998b). Features of Tril01, the trichothecene 3-O-acetyltransferase gene, related to the self-defense mechanism in Fusarium graminearum. Biosci Biotechnol Biochem 62(5):1033-1036.

Klich MA, Mullaney EJ, Daly CB, and Cary JW (2000). Molecular and physiological aspects of aflatoxin and sterigmatocystin biosynthesis by Aspergillus tamarii and A. ochraceoroseus. Appl Microbiol Biotechnol 53(5):605-609.

Klich MA, Yu J, Chang P-K, Mullaney EJ, Bhatnagar D, and Cleveland TE (1995). Hybridization of genes involved in aflatoxin biosynthesis to DNA of aflatoxigenic and non-aflatoxigenic Aspergillus. Appl. Microbiol Biotechnol 44:439-443.

Kusumoto K and Hsieh DP (1996). Purification and characterization of the esterases involved in aflatoxin biosynthesis in Aspergillus parasiticus. Can J Microbiol 8:804-810.

Lee T, Oh DW, Kim HS, Lee J, Kim YH, Yun SH, and Lee YW (2001). Identification of deoxynivalenol- and nivalenol-producing chemotypes of Gibberella zeae by using PCR. Appl Environ Microbiol 67(7):2966-2972.

Liang S-H, Skory CD, and Linz JE (1996). Characterization of the function of the ver-lA and ver-lB genes, involved in aflatoxin biosynthesis in Aspergillus parasiticus. Appl Environ Microbiol 62(12):4568-4575.

Luchese RH and Harrigan WF (1993). Biosynthesis of aflatoxin: the role of nutritional factors. J Appl Bacteriol 74:5-14.

Mahanti N, Bhatnagar D, Cary JW, Joubran J, and Linz JE (1996). Structure and function of fas-1A, a gene encoding a putative fatty acid synthetase directly involved in aflatoxin biosynthesis in Aspergillus parasiticus. Appl Environ Microbiol 62(1):191 -195.

Marasas WFO (1995). Fumonisins: their implications for human and animal health. Nat Toxins 3:193-198.

Marasas WFO (1996). Fumonisins: history, world-wide occurrence and impact. In: Jackson LS, DeVries JW, Bullerman LB eds. Fumonisins in Food. New York: Plenum Press. pp 1-17.

Matsushima K, Chang P-K, Yu J, Abe K, Bhatnagar D, and Cleveland TE (2001a). Pre-termination in aflR of Aspergillus sojae inhibits aflatoxin biosynthesis. Appl Microbiol Biotechnol 55:585-589.

Matsushima K, Yashiro K, Hanya Y, Abe K, Yabe K, and Hamasaki T (2001b). Absence of aflatoxin biosynthesis in koji mold (Aspergillus sojae). Appl Microbiol Biotechnol 55(6):771-776.

Matsumoto G, Wuchiyama J, Shingu Y, Kimura M, Yoneyama K, and Yamaguchi I (1999). The trichothecene biosynthesis regulatory gene from the type B producer Fusarium strains: sequence of Tri6 and its expression in Escherichia coli. Biosci Biotechnol Biochem 63(11):2001-2004.

Mayorga ME and Timberlake WE (1992). The developmentally regulated Aspergillus nidulans wA gene encodes a polypeptide homologous to polyketide and fatty acid syntheses. Mol Gen Genet 235:205-212.

McCormick SP, Bhatnagar D, and Lee LS (1987). Averufanin is an aflatoxin B, precursor between averantin and averufin in the biosynthetic pathway. Appl Environ Microbiol 53:14-16.

McCormick SP, Hohn TM, and Desjardins AE (1996). Isolation and characterization of Tri3, a gene encoding 15-O-acetyltrans-ferase from Fusarium sporotrichioides. Appl Environ Microbiol 62(2):353-359.

McCormick SP, Alexander NJ, Trapp SE, and Hohn TM (1999). Disruption of TRI101, the gene encoding trichothecene 3-O-acetyltransferase, from Fusarium sporotrichioides. Appl Environ Microbiol 65(12):5252-5256.

McGuire SM, Silva JC, Casillas EG, and Townsend CA (1996). Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodifferentiat-ing cyclization in aflatoxin biosynthesis essential to DNA interaction. Biochem 35:11470-11486.

Meyers DM, Obrian G, Du WL, Bhatnagar D, and Payne GA (1998). Characterization of aflJ, a gene required for conversion of pathway intermediates to aflatoxin. Appl Environ Microbiol 64:3713-3717.

Minto RE and Townsend CA (1997). Enzymology and molecular biology of aflatoxin biosynthesis. Chem Rev 97:2537-2555.

Mirocha CJ, Gilchrist DG, Shier WT, Abbas HK, and WMY Vesonder RF (1992). AAL toxins, fumonisins (biology and chemistry) and host-specificity concepts. Mycopothologia 117:47-56.

Mirocha CJ, Chen J, Xie W, Xu Y, Abbas HK, and Hogge LR (1996). Biosynthesis of fumonisin and AAL derivatives by Alternaria and Fusarium in laboratory culture. Adv Exp Med Biol 392:213-224.

Mori H and Kawai K (1989). Genotoxicity in rodent hepatocytes and carcinogenicity of mycotoxuis and related chemicals. In: Natori S, Hashimoto K, Ueno Y eds. Mycotoxim and Phycotoxins. Vol. 88. Amsterdam: Elsevier. pp 81 -90.

Motomura M, Chihaya N, Shinozawa T, Hamasaki T, and Yabe K (1999). Cloning and characterization of the O-methyl-transferase I gene (dmtA) from Aspergillus parasiticus associated with the conversions of DMST to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmato-cystin in aflatoxin biosynthesis. Appl Environ Microbiol 65(11):4987 -4994.

Muhitch MJ, McCormick SP, Alexander NJ, and Hohn TM (2000). Transgenic expression of the TRI101 or PDR5 gene increases resistance of tobacco to the phytotoxic effects of the trichothecene 4,15-diacetoxyscirpenol. Plant Sci 157(2):201-207.

Munkvold GP and Desjardins AE (1997). Fumonisins in maize: can we reduce their occurrence? Plant Dis 81:556-565.

Musser SM and Plattner RD (1997). Fumonisin composition in cultures of Fusarium moniliforme, Fusarium proliferatum, and Fusarium nygami. J Agric Food Chem 45:1169-1173.

Musser SM, Gay ML, Mazzola EP, and Plattner RD (1996). Identification of a new series of fumonisins containing 3-hydroxypyridine. J Pat Prod 59:970-972.

Nelson PE, Desjardins AE, and Plattner RD (1993). Fumonisins, mycotoxins produced by Fusarium species: biology, chemistry, and significance. Ann Rev Phytopathol 31:233-252.

Niehaus WG, Jr and Jiang W (1989). Nitrate induces enzymes of the marmitol cycle and suppresses versicolorin synthesis in Aspergillus parasiticus. Mycopathologia 107:131-137.

Papa KE (1979). Genetics of Aspergillus flavus: complementation and mapping of aflatoxin mutants. Genet Res 34:1-9.

Papa KE (1982). Norsolorinic acid mutant of Aspergillus flavus. J Gen Microbiol 128:1345-1348.

Papa KE (1984). Genetics of Aspergillus flavus: linkage of aflatoxin mutants. Can J Microbiol 30:68-73.

Payne GA (1998). Process of contamination by aflatoxin-producing fungi and their impacts on crops. In: Sinha KK, Bhatnagar D eds. Mycotoxins in Agriculture and Food Safety. Vol. 9. New York: Marcel Dekker. pp 279-306.

Payne GA and Hagler WM, Jr (1983). Effect of specific amino acids on growth and aflatoxin production by Aspergillus parasiticus and Aspergillus flavus in defined media. Appl Environ Microbiol 46(4):805-812.

Payne GA and Brown MP (1998). Genetics and physiology of aflatoxin biosynthesis. Annu Rev Phytopathol 36:329-362.

Payne GA, Nystrom GJ, Bhatnagar D, Cleveland TE, and Woloshuk CP (1993). Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus. Appl Environ Microbiol 59(1):156-162.

Plattner RD, Desjardins AE, Leslie JF, and Nelson PE (1996). Identification and characterization of Gibberella fujikuroi mating population A with rare fumonisin production phenotypes. Mycologia 88:416-424.

Prieto R and Woloshuk CP (1997). ordl, an oxidoreductase gene responsible for conversion of O-methylsterigmatocystin to aflatoxin in Aspergillus flavus. Appl Environ Microbiol 63(5):1661-1666.

Prieto R, Yousibova GL, and Woloshuk CP (1996). Identification of aflatoxin biosynthesis genes by genetic complementation in an Aspergillus flavus mutant lacking the aflatoxin gene cluster. Appl Environ Microbiol 62(10):3567-3571.

Proctor RH (2000). Fusarium toxins: Trichothecenes and Fumoni-sins. In: Cary JW, Linz JE, Bhatnagar D eds. Microbial Foodborne Diseases: Mechanisms of pathogenesis and toxin synthesis. Lancaster, PA: Technomic. pp 363-381.

Proctor RH, Hohn TM, and McCormick SP (1995a). Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene. Mol Plant Microbe Interact 8(4):593-601.

Proctor RH, Hohn TM, McCormick SP, and Desjardins AE (1995b). Tri6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides. Appl Environ Microbiol 61(5):1923-1930.

Proctor RH, Hohn TM, and McCormick SP (1997). Restoration of wild-type virulence to Tri5 disruption mutants of Gibberella zeae via gene reversion and mutant complementation. Microbiol 143:2583-2591.

Proctor RH, Desjardins AE, and Plattner RD (1999a). Biosynthetic and genetic relationships of B-series fumonisins produced by Gibberella fujikuroi mating population A. Nat Toxins 7(6):251-258.

Proctor RH, Desjardins AE, Plattner RD, and Hohn TM (1999b). A polyketide synthase gene required for biosynthesis of fumonisin mycotoxins in Gibberella fujikuroi mating population A. Fungal Genet Biol 27(1):100-112.

Reddy TV, Viswanathan L, and Venkitasubrarnanian TA (1971). High aflatoxin production on a chemically defined medium. Appl Environ Microbiol 22:393-396.

Reddy TV, Viswanathan L, and Venkitasubrarnanian TA (1979). Factors affecting aflatoxin production by Aspergillus para-siticus in a chemically defined medium. J Gen Microbiol 114(2):409-413.

Riley RT, Wang E, Schroeder JJ, Smith ER, Plattner RD, Abbas H, Yoo HS, and Merrill AH, Jr (1996). Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins. Nat Toxins 4(1):3-15.

Schroeder HW, Cole RS, Grigsby RD, and Hein HJ (1974). Inhibition of aflatoxin production and tentative identification of an aflatoxin intermediate "versicolor acetate" from treatment with dichlorvos. Appl Microbiol 27:394-399.

Scott PM (1993). Fumonisins. Internat J Food Microbiol 18:257-270.

Seo JA, Kim J-C, and Lee YW (1996). Isolation and characterization of two new type C fumonisins produced by Fusarium oxysporum. J Nat Prod 59:1003-1005.

Seo JA, Proctor RH, and Plattner RD (2001). Characterization of four clustered and coregulated genes associated with fumonisin biosynthesis in Fusarium verticillioides. Fungal Genet Biol 34(3):155-165.

Sharma RP and Kim YW (1991). Trichothecenes. In: Sharma RP, Salunkhe DK eds. Mycotoxins and Phytoalexins. Boca Raton, FL: CRC Press. pp 339-359.

Sharma RP and Salunkhe DK (1991). Mycotoxin and Phytoalexins in Human and Animal Health. Boca. Raton, FL: CRC Press, Inc.

Shier WT (1992). Sphingosine analogs: an emerging new class of toxins that includes the fumonisins. J Toxicol 11:241-257.

Silva JC and Townsend CA (1996). Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. J Biol Chem 272:804-813.

Silva JC, Minto RE, Barry CE, Holland KA, and Townsend CA (1996). Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus: expansion of the aflatoxin B1 biosynthetic cluster. J Biol Chem 271(23):13600-13608.

Skory CD, Chang P-K, Cary J, and Linz JE (1992). Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmato-cystin in aflatoxin biosynthesis. Appl Environ Microbiol 58(11):3527-3537.

Squire RA (1989). Ranking animal carcinogens: a proposed regulatory approach. Science 214:887-891.

Tag AG, Garifullina GF, Peplow AW, Ake C, Jr, Phillips TD, Hohn TM, and Beremand MN (2001). A novel regulatory gene Tri10, controls trichothecene toxin production and gene expression. Appl Environ Microbiol 67(11):5294-5302.

Takahashi T, Chang P-K, Matsushima K, Yu J, Koyama Y, Abe K, Bhatnagar D, and Cleveland TE (2002). Non-functionality of Aspergillus sojae aflR in a strain of Aspergillus parasiticus with a disrupted aflR gene. Appl Environ Microbiol 68:3737-3743.

Townsend CA (1997). Progress towards a biosynthetic rationale of the aflatoxin pathway. Pure Appl Chem 58:227-238.

Townsend CA, Christensen SB, and Trautwein K (1984). Hexanoate as a starter unit in polyketide synthesis. J Am Chem Soc 106:3868-3869.

Trail F, Chang P-K, Cary J, and Linz JE (1994). Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus. Appl Environ Microbiol 60(11):4078-4085.

Trail F, Nibedita M, and Linz J (1995a). Molecular biology of aflatoxin biosynthesis. Microbiol 141:755-765.

Trail F, Mahanti N, Rarick M, Mehigh R, Liang SH, Zhou R, and Linz JE (1995b). Physical and transcriptional map of an aflatoxin gene cluster in Aspergillus parasiticus and functional disruption of a gene involved early in the aflatoxin pathway. Appl Environ Microbiol 61(7):2665-2673.

Trapp SC, Hohn TM, McCormick S, and Jarvis BB (1998). Characterization of the gene cluster for biosynthesis of macrocyclic trichothecenes in Myrothecium roridum. Mol Gen Genet 257(4):421-432.

Van der Watt JJ (1977). Sterigmatocystin. In: Purchase IFH ed. Mycotoxins. New York: Elsevier Scientific Publishing Co. pp 368-382.

Van Egmond HP (1989b). Current situation on regulations for mycotoxins: Overview of tolerances and status of standard methods of sampling and analysis. Food Addit Contam 6:134-188.

Vederas JC and Nakashima TT (1980). Biosynthesis of averufin by Aspergillus parasiticus: detection of 180-label by 13C nuclear magnetic resonance isotope shifts. J Chem Soc Chem Commun 4:183-185.

Wang H, Jones C, Ciacci-Zanella J, Holt T, Gilchrist DG, and Dickman MB (1996). Fumonisins and Alternaria alternate lycopersici toxins: Sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. Proc Natl Acad Sci USA 93:3461-3465.

Watanabe CMH, Wilson D, Linz JE, and Townsend CA (1996). Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid syntheses and a polyketide synthase in the biosynthesis of aflatoxin B1. Chem Biol 3:463-469.

Wattenberg EV, Badria FA, and Shier WT (1996). Activation of mitogen-activated protein kinase by the carcinogenic myco-toxin fumonisin B1. Biochem Biophys Res Commun 14;227(2):622-627.

Wilson RA, Gardner HW, and Keller NP (2001). Cultivar-dependent expression of a maize lipoxigenase responsive to seed infesting fungi. Mol Plant Microbe Interact 14(8):980-987.

Woloshuk CP and Payne GA (1994). The alcohol dehydrogenase adh1 is induced in Aspergillus flavus grown on medium conducive to aflatoxin biosynthesis. Appl Environ Microbiol 60:670-676.

Woloshuk CR and Prieto R (1998). Genetic organization and function of aflatoxin B1 biosynthetic genes. FEMS Microbiol Lett:1-8.

Woloshuk CP, Foutz KR, Brewer JF, Bhatnagar D, Cleveland TE, and Payne GA (1994). Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesis. Appl Environ Microbiol 60(7):240814.

Woloshuk CP, Cavaletto JR, and Cleveland TE (1997). Inducers of aflatoxin biosynthesis from colonized maize kernels are generated by an amylase activity from Aspergillus flavus. Phytopathol 87:164-169.

Wright MS, Greene-McDowelle DM, Zeringue HJ, Bhatnagar D, and Cleveland TE (2000). Effects of volatile aldehydes from Aspergillus-resistant varieties of corn on Aspergillus parasiticus growth and aflatoxin biosynthesis. Toxicon 38:1215-1223.

Wuchiyama J, Kimura M, and Yamaguchi I (2000). A trichothecene efflux pump encoded by Tri102 in the biosynthesis gene cluster of Fusarium graminearum. J Antibiot (Tokyo) 53(2):196-200.

Xu J-R and Leslie JF (1996). A genetic map of Gibberella fujikuroi mating population A (Fusarium moniliforme). Genetics 143(1):175-189.

Yabe K and Hamasaki T (1993). Stereochemistry during aflatoxin biosynthesis: cyclase reaction in the conversion of versiconal to versicolorin B and racemization of versiconal hemiacetal acetate. Appl Environ Microbiol 59(8):2493-2500.

Yabe K, Ando Y, and Hamasaki T (1988a). Biosynthetic relationship among aflatoxins Bj, B2, Gj, and G2. Appl Environ Microbiol 54(8):2101-2106.

Yabe K, Nakamura H, Ando Y, Terakado N, Nakajirni H, and Hamasaki T (1988b). Isolation and characterization of Aspergillus parasiticus mutants with impaired aflatoxin production by a novel tip culture method. Appl Environ Microbiol 54(8):2096-2100.

Yabe K, Ando Y, Hashimoto J, and Hamasaki T (1989). Two distinct O-methyltransferases in aflatoxin biosynthesis. Appl Environ Microbiol 55(9):2172-2177.

Yabe K, Ando Y, and Hamasaki T (1991a). A metabolic grid among versiconal hemiacetal acetate, versiconol acetate, versiconol and versiconal during aflatoxin biosynthesis. J Gen Microbiol 137:2469-2475.

Yabe K, Nakamura Y, Nakajima H, Ando Y, and Hamasaki T (1991b). Enzymatic conversion of norsolinic acid to averufin in aflatoxin biosynthesis. Appl Environ Microbiol 57:1340-1345.

Yabe K, Matsuyama Y, Ando Y, Nakajima H, and Hamasaki T (1993). Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin. Appl Environ Microbiol 59(8):2486-2492.

Yabe K, Matsushima K, Koyama T, and Hamasaki T (1998). Purification and characterization of O-methyltransferase I involved in conversion of demethylsterigmatocystin to sterigmatocystin and of dihydrodemethylsterigmatocystin to dihydrosterigmatocystin during aflatoxin biosynthesis. Appl Environ Microbiol 64:166-171.

Yabe K, Nakamura M, and Hamasaki T (1999). Enzymatic formation of G-group aflatoxins and biosynthetic relationship between G- and B-group aflatoxins. Appl Environ Microbiol 65(9):3867-3872.

Yao RC and Hsieh DPH (1974). Step of dichlorvos inhibition in the pathway of aflatoxin biosynthesis. Appl Microbiol 28(1):52-57.

Yu J-H and Leonard TJ (1995). Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase. J Bacteriol 177(16):4792-4800.

Yu J, Cary JW, Bhatnagar D, Cleveland TE, Keller NP, and Chu FS (1993). Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. Appl Environ Microbiol 59:3564-3571.

Yu J, Chang P-K, Cary JW, Wright M, Bhatnagar D, Cleveland TE, Payne GA, and Linz JE (1995a). Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus. Appl Environ Microbiol 61(6):2365-2371.

Yu J, Chang PK, Payne GA, Cary JW, Bhatnagar D, and Cleveland TE (1995b). Comparison of the omtA genes encoding O-methyltransferases involved in aflatoxin biosynthesis from Aspergillus parasiticus and A. flavus. Gene 163:121-125.

Yu J, Chang P-K, Cary JW, Bhatnagar D, and Cleveland TE (1997). avnA, a gene encoding a cytochrome P-450 monooxygenase is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus. Appl Environ Microbiol 63(4):1349-1356.

Yu J, Chang P-K, Cary JW, Ehrlich KC, Montalbano B, Dyer JM, Bhatnagar D, and Cleveland TE (1998). Characterization of the critical amino acids of an Aspergillus parasiticus cytochrome P450 monooxygenase encoded by ordA involved in aflatoxin Bi, Gi, B2, and G2 biosynthesis. Appl Environ Microbiol 64:4834 -4841.

Yu J, Chang P-K, Bhatnagar D, and Cleveland TE (2000a). Genes encoding cytochrome P450 and monooxigenase enzymes define one end of the aflatoxin pathway gene cluster in Aspergillus parasiticus. Appl Microbiol Biotechnol 53:583-590.

Yu J, Woloshuk CP, Bhatnagar D, and Cleveland TE (2000b). Cloning and characterization of avfA and omtB genes involved in aflatoxin biosynthesis in three Aspergillus species. Gene 248:157-167.

Yu J, Chang P-K, Bhatnagar D, and Cleveland TE (2000c). Cloning of sugar utilization gene cluster in Aspergillus parasiticus. Biochim Biophys Acta 1493:211-214.

Yu J, Chang PK, Bhatnagar D, and Cleveland TE (2003). Cloning and functional expression of an esterase gene in Aspergillus parasiticus. Mycopathologia 156:227-234.

Yu J-H, Butchko RA, Fernandes M, Keller NP, Leonard TJ, and Adams TH (1996). Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Curr Genet 29:549-555.

Zeringue HJ (1991). Effect of C6 to C9 alkenals on aflatoxin production in corn, cottonseed, and peanuts. Appl Environ Microbiol 57(8):2433-2434.

Zeringue HJ (1996). Possible involvement of lipoxygenase in a defense response in aflatoxigenic Aspergillus-cotton plant interaction. Can J Bot 74:98-102.

Zeringue HJ, Bhatnagar D, and Cleveland TE (1993). C15H24 volatile compounds unique to aflatoxigenic strains of Aspergillus flavus. Appl Environ Microbiol 59(7): 2264- 2270.

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